Although the role of immunosuppressive agent in each individual is unclear, the overall degree of i

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1 Benign polyclonal lymphoproliferative disorder is acute infectious mononucleosis disease developed two to eight weeks after the start of the immunosuppressive therapy. This disorder is characterized by polyclonal B cell proliferation with normal cytogenetics and no evidence of the immunoglobulin gene rearrangements to suggest malignant. It represents approximately 55 percent of cases.
2 The second EBV induced disorder is similar to the first, but is characterized by polyclonal B cell proliferation and malignant transformation elements, as clonal cytogenetic abnormalities or rearrangements of immunoglobulin gene. These constitute about 30 percent of cases.
3 The last disorder, which represents about 15 percent of cases, it is usually a situation with localized happy potter teddington extranodal solid tumors characterized by monoclonal proliferation of malignant B cells with cytogenetic abnormalities and rearrangements of immunoglobulin gene. Studies in heart transplants indicate that the rate of DNA aneuploidy in these tumors is lower than that of lymphomas with the same histological grade and proliferation rate of cells occurring in immunocompetent individuals. These findings are similar to those found in lymphomas associated with AIDS. More than 50 percent of patients with PTLD have extranodal masses. Involved organs happy potter teddington of the stomach and intestine, lung, skin, liver, central nervous system and the allograft. More specifically, 20 to 25 percent have disease of the central nervous system, which is rare in the general population and a similar percentage is infiltrative lesions of the allograft. Participation of the allograft may lead to malfunction, including renal, cardiac and respiratory insufficiency. The post-transplant lymphoproliferative tumors that are not directly related to EBV appear to differ clinically from those with EBV-related tumors. One study examined the clinical and survival in 11 recipients with lymphoma B-cells was not due to EBV and compared with those in 21 patients with EBV lymphomas. Tumors that are not due to EBV presented much later (2324 vs. 546 days), suggesting that their frequency may increase with time and was much stronger (median survival 37 months versus one). Effect
The overall incidence of lymphoproliferative diseases is about 1 percent, from 30 to 50 times higher than in the general population, a trend toward higher frequency. The risk of PTLD is greater in patients with more intense immunosuppression. This may partially explain the variability in the incidence of PTLD in different types of transplants. The frequency ranges from 1 to 2 percent in liver, 1 to 3 percent in patients with renal transplantation, from 2 to 6 percent in heart transplantation, 2-9 percent lung transplants and 11 to 33 percent in intestinal or multiorgan transplantation. Risk Factors
The main risk factors when developing happy potter teddington a post-transplant lymphoproliferative happy potter teddington disorder is the degree of immunosuppression and EBV load address. Additional risk factors include the time after transplantation, the recipient's age and ethnicity. -Vathmos Immunosuppression
Although the role of immunosuppressive agent in each individual is unclear, the overall degree of immunosuppression is a major determinant of the development happy potter teddington of a lymphoproliferative disorder. Immunosuppression, at least in part, acts through altering the EBV-specific T cell anosia.Ta EBV-infected cells are deemed to be controlled by the cytotoxic T cells, thereby disturbing the balance between cell division and death of EBV- B cells. The disruption happy potter teddington of cell function favors the promotion of the development of PTLD. A value with solid organ transplantation are at increased risk of PTLD especially those undergoing immunosuppression heavily and those who are ektetheim